2022.03.04 Zhou Li's student review was published in the international academic journal J Hematol Oncol

On March 4, 2022, Zhou Li, a student in our room, published a review paper entitled "Circadian rhythms and cancers: the intrinsic link sand therapeutic potentials" in the international academic journal J Hematol Oncol (impact factor 17.388).

Circadian rhythm is a system that is evolutionarily conserved and achieves systemic homeostasis by coordinating the physiological activities of all organs. It contains a wide variety of physiological processes, including sleep-wake cycles, feeding-fasting cycles, and activity-rest cycles, among others. Temporary dysregulation of circadian rhythms may lead to short-term discomfort, while long-term circadian dysfunction can lead to dysfunction of the body, which increases the risk of multiple diseases, especially cancer. In fact, both existing epidemiological and experimental evidence demonstrate an intrinsic link between circadian dysregulation and cancer. Therefore, in-depth understanding of the molecular mechanisms of circadian rhythms is providing new options for cancer treatment, namely by regulating the body's biological clock. This article first summarizes the regulatory mechanisms of circadian rhythms and their regulatory role in cancer. In addition, this paper also discusses the potential mechanisms by which several types of circadian rhythm disturbances (including sleep-wake, eating-fasting, and activity-rest) contribute to cancer progression, helping to expand our understanding of cancer occurrence and development from a rhythmic perspective. Finally, this paper summarizes the potential applications of regulating circadian rhythms in cancer treatment, which is expected to provide an optional treatment strategy for cancer patients.