2020.04.15 Dr Huang Zhao's review was published in the international journal Molecular CancerOn 15 April 2020, The Role of Long Noncoding RNAs in Hepatocellular Carcinoma (HCC) is a new form of Hepatocellular Carcinoma that can contribute to liver Cancer, such as liver Cancer, and Hepatocellular Carcinoma. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Early liver cancer research has focused on the functional analysis of protein-coding genes, as proteins have long been considered implementors of various biological processes. However, this part of the coding genes only accounts for 2% of the human genome, up to 98% of the genome after transcription into RNA does not encode proteins, called non-coding RNA (ncRNA), these ncRNA also have important biological effects. Some long non-coding Rnas (lncrnas) play an important role in hepatitis virus infection and immune response, liver development and regeneration, and the maintenance of REDOX homeostasis during liver detoxification. During the occurrence and development of liver cancer, lncRNA interacts with DNA, RNA and proteins to affect the proliferation, metabolism, dryness and metastasis of liver cancer cells. These findings suggest that some lncrnas may serve as potential tumor markers or drug targets for HCC. |