Canhua Huang's Lab

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156. Tian H, Zhou L, Wang Y, Nice EC, Huang C*, Zhang H*. A targeted nanomodulator capable of manipulating tumor microenvironment against metastasis. J Control Release. 2022;348:590-600.

155. Qin S, Li B, Ming H, Nice EC, Zou B*, Huang C*. Harnessing redox signaling to overcome therapeutic-resistant cancer dormancy. Biochim Biophys Acta Rev Cancer. 2022;1877(4):188749.

154. Luo M, Zhou L, Huang Z, Li B, Nice EC, Xu J*, Huang C*. Antioxidant Therapy in Cancer: Rationale and Progress. Antioxidants. 2022;11(6):1128.

153. Huang Z, Zhang Z, Zhou C*, Liu L*, Huang C*. Epithelial-mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities. MedComm. 2022;3(2):e144.

152. Ming H, Li B, Tian H, Zhou L, Jiang J, Zhang T, Qiao L, Wu P, Nice EC, Zhang W, He W*, Huang C*, Zhang H*. A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer. Mater Today Bio. 2022;15:100289.

151. Shi J, Zhou L, Huang H, Peng L, Xie N, Nice EC, Fu L, Jiang C*, Huang C*. Repurposing oxiconazole against colorectal cancer via PRDX2-mediated autophagy arrest. Int J Biol Sci. 2022;18(9):3747-61.

150. Fan Q, Zuo J, Tian H, Huang C, Nice EC, Shi Z*, Kong Q*. Nanoengineering a metal-organic framework for osteosarcoma chemo-immunotherapy by modulating indoleamine-2,3-dioxygenase and myeloid-derived suppressor cells. J Exp Clin Canc Res. 2022;41(1):1-17.

149. He B, Huang Z, Huang C*, Nice EC*. Clinical applications of plasma proteomics and peptidomics: towards precision medicine. Proteomics Clin Appl. 2022;2100097.

148. Liu R, Peng L, Zhou L, Huang Z, Zhou C*, Huang C*. Oxidative stress in cancer immunotherapy: molecular mechanisms and potential applications. Antioxidants (Basel). 2022;11(5):853.

147. Wang Y, Huang Z, Li B, Liu L*, Huang C*. The emerging roles and therapeutic implications of epigenetic modifications in ovarian cancer. Front Endocrinol. 2022;766.

146. Peng L, Jiang J, Zhou L, Nice EC, Huang C*. A cellular thermal shift assay for detecting amino acid sites involved in drug target engagement. STAR Protoc. 2022;101423.

145. Zuo J, Zhang Z, Luo M, Zhou L, Nice EC, Zhang W, Wang C*, Huang C*. Redox signaling at the crossroads of human health and disease. MedComm. 2022;3(2):e127.

144. Zhou L, Zhang Z, Nice EC, Huang C*, Zhang W*, Tang Y*. Circadian rhythms and cancers: the intrinsic links and therapeutic potentials. Mol Cancer. 2022;15(1):21.

143. Zuo J, Zhang Z, Li M, Yang Y, Zheng B, Wang P*, Huang C*, Zhou S*. The crosstalk between reactive oxygen species and noncoding RNAs: from cancer code to drug role. Mol Cancer. 2022;21(1):30.

142. Weng N, Qin S, Liu J, Huang X, Jiang J, Zhou L, Zhang Z, Xie N, Wang K, Jin P, Luo M, Peng L, Nice EC, Goel A, Han S*, Huang C*, Zhu Q*. Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma. Acta Pharm Sin B. doi:10.1016/j.apsb.2022.01.018.

141. Luo M, Huang Z, Yang X, Chen Y, Jiang J, Zhang L, Zhou L, Qin S, Jin P, Fu S, Peng L, Li B, Fang Y, Pu W, Gong Y, Liu Y, Ren Z, Liu QL, Wang C, Xiao F, He D, Zhang H, Li C, Xu H, Dai L, Peng Y, Zhou ZG, Huang C*, Chen HN*. PHLDB2 mediates cetuximab resistance via interacting with EGFR in latent metastasis of colorectal cancer. Cell Mol Gastroenterol Hepatol. 2021;S2352-345X(21):00261-7.

140. Zhang Z, Qin S, Chen Y, Zhou L, Yang M, Tang Y, Zuo J, Zhang J, Mizokami A, Nice EC, Chen H*, Huang C*, Wei X*. Inhibition of NPC1L1 disrupts adaptive responses of drug-tolerant persister cells to chemotherapy. EMBO Mol Med. 2022;14(2):e14903.

139. Yang M, Zhang Z, Nice EC, Wang C*, Zhang W*, Huang C*. Psychological intervention to treat distress: An emerging frontier in cancer prevention and therapy. Biochim Biophys Acta Rev Cancer. 2021;1877(1):188665.

138. Peng L, Jiang J, Chen H, Zhou L, Huang Z, Qin S, Jin P, Luo M, Li B, Shi J, Xie N, Deng L, Liou Y, Nice EC, Huang C*, Wei Y. Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer. Cell Rep. 2021;37(9):110069.

137. Wang Z, Guo K, Liu Y, Huang C*, Wu M*. Dynamic impact of virome on colitis and colorectal cancer: immunity, inflammation, prevention and treatment. Semin Cancer Biol. 2021;S1044-579X(21):00254-6.

136. Li B, Huang Y, Ming H, Nice EC, Xuan R*, Huang C*. Redox Control of the Dormant Cancer Cell Life Cycle. Cells. 2021;10(10):2707.

135. Zheng X, Liu R, Zhou C, Yu H, Luo W, Zhu J, Liu J, Zhang Z, Xie N, Peng X, Xu X, Cheng L, Yuan Q, Huang C*, Zhou X*. ANGPTL4-mediated promotion of glycolysis facilitates the colonization of Fusobacterium nucleatum in colorectal cancer. Cancer Res. 2021;81(24):6157-6170.

134. Jiang J, Li B, He W*, Huang C*. Dietary serine supplementation: Friend or foe? Curr Opin Pharmacol. 2021;61:12-20.

133. Peng L, Yin HY*, Huang C*. CNMa-CNMa receptor at microbiome-gut-brain axis: novel target to regulate feeding decision. Signal Transduct Target Ther. 2021;6(1):283.

132. Tian H, Zhao S, Nice EC, Huang C, He W*, Zou B*, Lin J*. A cascaded copper-based nanocatalyst by modulating glutathione and cyclooxygenase-2 for hepatocellular carcinoma therapy. J Colloid Interface Sci. 2021;607(2):1516-1526.

131. An Y, Jiang J, Zhou L, Shi J, Jin P, Li L, Peng L, He S, Zhang W, Huang C, Zou B*, Xie N*. Peroxiredoxin 1 is essential for natamycin-triggered apoptosis and protective autophagy in hepatocellular carcinoma. Cancer Lett. 2021;521:210-223.

130. Gao W, Huang Z, Duan J, Nice EC, Lin J*, Huang C*. Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A. Mol Oncol. 2021;15(12):3527-44.

129. Luo M, Yang X, Chen HN, Nice EC*, Huang C*. Drug resistance in colorectal cancer: An epigenetic overview. Biochim Biophys Acta Rev Cancer. 2021;1876(2):188623.

128. Zhang Z, Shi J, Nice EC, Huang C*, Shi Z*. The Multifaceted Role of Flavonoids in Cancer Therapy: Leveraging Autophagy with a Double-Edged Sword. Antioxidants (Basel). 2021;10(7):1138.

127. Su M, Zhang Z, Zhou L, Han C, Huang C*, Nice EC*. Proteomics, Personalized Medicine and Cancer. Cancers (Basel). 2021;13(11):2512.

126. Zhang P, Zou B, Liou YC*, Huang C*. The pathogenesis and diagnosis of sepsis post burn injury. Burns Trauma. 2021;9:047.

125. Wang Z, Guo K, Gao P, Pu Q, Lin P, Qin S, Xie N, Hur J, Li C*, Huang C*, Wu M*. Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease. Theranostics. 2021;11(15):7491-7506.

124.Wang Z, Pu Q*, Huang C*, Wu M*. Crosstalk Between Lung and Extrapulmonary Organs in Infection and Inflammation. Adv Exp Med Biol. 2021;1303:333-50.

123. Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, Verkhratsky A, Sperlagh B, Yu S, Huang C*, Tang Y*. From purines to purinergic signalling: molecular functions and human diseases. Signal Transduct Target Ther. 2021; 6(1):162.

122. Liu J, Huang Z, Chen HN, Qin S, Chen Y, Jiang J, Zhang Z, Luo M, Ye Q, Xie N, Zhou Z, Wei Y, Xie K*, Huang C*. ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer. Oncogene. 2021; 40(19):3394-407.

121. Ming H, Li B, Zhou L, Goel A*, Huang C*. Long non-coding RNAs and cancer metastasis: Molecular basis and therapeutic implications. Biochim Biophys Acta Rev Cancer. 2021; 1875(2):188519.

120. Xie N, Zhang L, Gao W, Huang C, Huber PE, Zhou X, Li C*, Shen G*, Zou B*. NAD + metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020; 5(1):227.

119. Qin S, Jiang J, Lu Y, Nice EC, Huang C*, Zhang J*, He W*. Emerging role of tumor cell plasticity in modifying therapeutic response. Signal Transduct Target Ther. 2020; 5(1):228.

118. Zhou L, Zhang Z, Huang Z, Nice EC, Zou B*, Huang C*. Revisiting cancer hallmarks: insights from the interplay between oxidative stress and non-coding RNAs. Molecular Biomedicine. 2020.

117.   Peng L, Jiang J, Tang B, Nice EC, Zhang YY*, Xie N*. Managing therapeutic resistance in breast cancer: from the lncRNAs perspective. Theranostics. 2020; 10(23):10360-77.

116. Li B, Jiang J, Assaraf YG, Xiao H, Chen Z-S*, Huang C*. Surmounting Cancer Drug Resistance: New Insights from the perspective of N6-Methyladenosine RNA Modification. Drug Resistance Updates. 2020; 53:100720.

115. Jiang J, Peng L, Wang K*, Huang C*. Moonlighting Metabolic Enzymes in Cancer: New Perspectives on the Redox Code. Antioxid Redox Signal. 2020; 34(13):979-1003.

114. Zhang Z, Zhou L, Xie N, Nice EC, Zhang T*, Cui Y-P*, Huang C*. Overcoming cancer therapeutic bottleneck by drug repurposing. Signal Transduct Target Ther. 2020; 5(1):113.

113. Zhang P, Li T, Wu X, Nice EC, Huang C*, Zhang Y*. Oxidative stress and diabetes: antioxidative strategies. Front Med. 2020; 14(5):583-600.

112. Huang Z, Zhou J-K, Peng Y, He W*, Huang C*. The role of long noncoding RNAs in hepatocellular carcinoma. Mol Cancer. 2020; 19(1):77.

111. Huang Z, Zhou J-K, Wang K, Chen H-N, Qin S, Liu J, Luo M, Chen Y, Jiang J, Zhou L, Zhu L, He J, Li J, Pu W, Gong Y, Li J, Ye Q, Dong D, Hu H, Zhou Z, Dai L, Wei Y, Huang C*, Wei X*, Peng Y*. PDLIM1 inhibits tumor metastasis through activating Hippo signaling in hepatocellular carcinoma. Hepatology. 2020; 71(5):1643-59.

110. Zhang Z, Gao W, Zhou L, Chen
Y, Qin S, Zhang L, Liu J, He Y, Lei Y, Chen H-N, Han J, Zhou Z-G, Nice EC, Li C, Huang C*, Wei X*. Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy. Theranostics. 2019; 9(17):4878-4892.

109. He Y, Mohamedali A, Huang C, Baker MS*, Nice EC*. Oncoproteomics: Current status and future opportunities. Clin Chim Acta. 2019; 495:611-624.

108: An Y, Zhou L, Huang Z, Nice EC, Zhang H*, Huang C*. Molecular insights into cancer drug resistance from a proteomics perspective. Expert Rev Proteomics. 2019; 29:1-17.

107: Jiang J, Zhang L, Chen H-N, Lei Y, Zhang T, Wang Y, Jin P, Lan J, Zhou L, Huang Z, Li B, Liu Y, Gao W, Xie K, Zhou L, Nice EC, Peng Y, Cao Y, Wei Y, Wang K*, Huang C*. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma. Autophagy. 2019; 25:1-17.

106: Chen H-N, Chen Y, Zhou Z-G, Wei Y, Huang C*. A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery. Autophagy. 2019;15(4):733-734.


105: Zhou L, Gao W, Wang K, Huang Z, Zhang L, Zhang Z, Zhou J, Nice EC, Huang C. Brefeldin A Inhibits Colorectal Cancer Growth by Triggering Bip/Akt-regulated Autophagy. FASEB J. 2019;33(4):5520-5534.

104:Wang K, Jiang J, Lei Y, Zhou S, Wei Y, Huang C. Targeting Metabolic-redox Circuits for Cancer Therapy. Trends Biochem Sci. Trends Biochem Sci. 2019;44(5):401-414.

103: Zhang Z, Zhang L, Zhou L, Lei Y, Zhang Y*, Huang C*. Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress. Redox Biol. 2018; doi: 10.1016/j.redox.2018.11.005.

102: Chen Y, Chen H-N, Wang K, Zhang L, Huang Z, Liu JY, Zhang Z, Luo MC, Lei YL, Peng Y, Zhou Z-G, Wei YQ, Huang C*. Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma. J Hepatol. 2019;70(1): 66-77.

101: Liu Y, Guo JZ, Liu Y, Wang K, Ding W, Wang H, Liu X, Zhou S, Lu XC, Yang HB, Xu C, Gao W, Zhou L, Wang YP, Hu W, Wei Y, Huang C*, Lei QY*. Nuclear Lactate Dehydrogenase A Senses ROS to Produce α-Hydroxybutyrate for HPV-induced Cervical Tumor Growth. Nat Commun. 2018;9(1):4429.

100: Peng L, Cantor DI, Huang C, Wang K, Baker MS*, Nice EC*.Tissue and plasma proteomics for early stage cancer detection. Mol Omics. 2018;14(6):405-423.

99: Lan J, Huang Z, Han J, Shao J*, Huang C*. Redox regulation of microRNAs in cancer. Cancer Lett. 2018;418:250-259.

98: Jin P, Lan J, Wang K, Baker MS, Huang C*, Nice EC*. Pathology, proteomics and the pathway to personalised   medicine. Expert Rev Proteomics. 2018;16:1-13.

97:   Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Nice EC, Wu M*, Huang C*, Wei Y. Identification of Annexin A2 as a Specific Bleomycin Target to Induce Pulmonary Fibrosis by Impeding TFEB-mediated Autophagic Flux. Autophagy. 2018;14(2):269-282.

96: Jiang J, Wang K, Chen Y, Chen H, Nice EC*, Huang C*. Redox regulation in tumor cell epithelial mesenchymal transition: molecular basis and therapeutic strategy. Signal Transduct Target Ther. 2017; 2:17036

95: Jin P, Wang K, Huang C*, Nice EC*. Mining the fecal proteome: from biomarkers to personalised medicine. Expert Rev Proteomics. 2017;14(5):445-459.

94: Fu S, Liu X, Luo M, Xie K, Nice EC, Zhang H*, Huang C*.Proteogenomic studies on cancer drug resistance:   towards biomarker discovery and target identification. Expert Rev Proteomics. 2017;14(4): 351-362.

93: Zhou L, Wen J, Huang Z, Nice EC, Huang C, Zhang H*, Li Q*. Redox proteomics screening cellular factors associated with oxidative stress in hepatocarcinogenesis. Proteomics Clin Appl. 2017;11(3-4).

92: Wang K, Gao W, Dou Q, Chen H, Li Q, Nice EC, Huang C*. Ivermectin Induces PAK1-mediated Cytostatic Autophagy in Breast Cancer. Autophagy. 2016;12(12)2498-2499.

91: Huang Z, Ma L, Huang C, Li Q*, Nice EC*. Proteomic profiling of human plasma for cancer biomarker discovery. Proteomics. 2017;17(6).

90: Dou Q, Chen H, Wang K, Yuan K, Lei Y, Li K, Lan J, Chen Y, Huang Z, Xie N, Zhang L, Xiang R, Nice EC, Wei Y and Huang C*. Ivermectin induces cytostatic autophagy by blocking PAK1/Akt axis in breast cancer. Cancer Res. 2016;76(15):4457-69.

89: Li X, He S, Li R, Zhou X, Zhang S, Yu M, YeY, Wang Y, Huang C*, Wu M*. Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-ediated immune activation and infiltration. Nat Microbiol. 2016;1(10):16132.

88: Xie N, Yuan K, Zhou L, Wang K, Chen H, Lei Y, Lan J, Pu Q, Gao W, Zhang L, Shen G, Li Q, Xiao H, Tang H, Xiang R, He M, Feng P, Nice EC, Wei Y, Zhang H*, Yang J* and Huang C*. PRKAA1/AMPK restricts HBV replication through promotion of autophagic degradation. Autophagy. 2016;12(9):1507-20.

87: Zhang J, Feng H, Zhao J, Feldman ER, Chen S, Yuan W, Huang C, Akbari, Tibbetts SA, Feng P. IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Rep. 2016;16(2):405-18.

86: Chen H, Wang S, Zhang H, Nice EC, Huang C*. Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities. Expert Rev Anticancer Ther. 2016;16(8):827-38.

85: Liu Y, Li Q, Zhou L, Xie N, Nice EC, Zhang H*, Huang C* and Lei Y*. Cancer drug resistance: redox resetting renders a way. Oncotarget. 2016;7(27):42740-42761.

84: Huang Z, Zhou L, Chen Z, Nice EC, Huang C*. Stress Management by Autophagy: Implications for Chemoresistance. Int J Cancer. 2016;139(1):23-32.

83: Zhou L, Wang K, Li Q, Nice EC, Zhang H*, Huang C*. Clinical proteomics-driven precision medicine for targeted cancer therapy: current overview and future perspectives. Expert Rev Proteomics. 2016;13(4):367-81.

82: Chen HN, Yuan K, Xie N, Wang K, Huang Z, Chen Y, Dou Q, Wu M, Nice EC, Zhou ZG*, Huang C*.   PDLIM1 stabilizes the E-cadherin/Beta catenin complex to prevent epithelial mesenchymaltransition and metastatic potential of colorectal cancer cells. Cancer Res. 2016;76(5):1122-34.

81: Li X, He S, Zhou X, Ye Y, Tan S, Zhang S, Li R, Yu M, Jundt MC, Hidebrand A, Wang Y, Li G*, Huang C*, Wu M*. Lyn delivers bacteria to lysosomes for eradication throughTLR2-initiated autophagy related phagocytosis. PLoS Pathog. 2016;12(1):e1005363.

80: Yuan K, Lei Y, Chen H, Chen Y, Zhang T, Li K, Xie N, Wang K, Feng X, Pu Q, Yang W, Wu M, Xiang R, Feitelson MA, Nice EC, Wei Y, Huang C*. HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3. Cell Death Differ. 2016;616–627.

79: Zhou L, Li Q, Wang J, Huang C*, Nice EC. Oncoproteomics: Trials and Tribulations. Proteomics Clin Appl. 2016;10(4):516-31.

78: Zhang L, Wang K, Lei Y, Li Q, Nice EC, Huang C*. Redox Signaling:Potential Arbitrator of Autophagy and Apoptosis in Therapeutic Response. Free Radical Bio Med. 2015;89:452-465.

77: Jiang J, Wang K, Nice EC, Zhang T, Huang C*. High-throughput screening of cellular redox sensors using modern redox proteomics approaches. Expert Rev Proteomics. 2015;12(5):543-55.

76: Ren F,Wang K, Zhang T, Jiang J, Nice EC*,Huang C*. New insights into redox regulationof stem cell self-renewal anddifferentiation. Biochim Biophys Acta. 2015;1850(8):1518-26.

75: Feng S, Zhou L, Huang C, Xie K*, Nice EC*. Interactomics: toward protein function andregulation. Expert Rev Proteomics. 2015;12(1):37-60.

74: Li X, Ye Y,Zhou X, Huang C*, Wu M*. Atg7 Enhances Host Defense against Infection via Downregulation of Superoxide but Upregulation of Nitric Oxide. J Immunol. 2015;194(3):1112-21.

73: Liu R, HuangS, Lei Y, Zhang T, Wang K, Liu B, Nice EC, Xiang R, Xie K, Li J*, Huang C*. FGF8 promotes   colorectal cancer growth and metastasis by activating   YAP1. Oncotarget. 2015;6(2):935-52.

72: Yuan K, Liu Y, Zhang L, Lan J, Gao W, Dou Q, Nice EC*, Huang C*. Thiol-based redox proteomicsin cancer research. Proteomics. 2015;15(2-3):287-99.

71: Lei Y, WangK, Deng L, Chen Y, Nice EC, Huang C*. Redox Regulation of Inflammation:Old Elements, a New Story. Med Res Rev. 2015 ;35(2):306-40.

70: Feng S, ZhouL, Nice EC*, Huang C*. Fibroblast growth factor receptors: multifactorial-contributorsto tumor initiation and progression. Histol Histopathol. 2015;30(1):13-31.

69: Yang W, ZouL, Huang C, Lei Y*. Redox regulation of cancer metastasis: molecularsignaling and therapeutic opportunities. Drug Dev Res. 2014;75(5):331-41.

68: Liu R, Li J, Zhang T, Zou L, Chen Y, Wang K, Lei Y, Yuan K, Li Y, Lan J, Cheng L, Xie N, Xiang R, Nice EC, Huang C*, Wei Y. Itraconazole suppresses the growth of glioblastomathrough induction of autophagy: Involvement of abnormal cholesterol trafficking. Autophagy. 2014;10(7):1241-55.

67: Wang K, Huang C, Nice E*. Recent advances in proteomics: towards the human proteome.Biomed Chromatogr. 2014;28(6):848-57.

66: Wang K, Huang C*, Nice EC*. Proteomics, genomics and transcriptomics: their emerging roles inthe discovery and validation of colorectal cancer biomarkers. Expert Rev Proteomics. 2014;11(2):179-205.

65: Li X, Zhou X, Ye Y, Li Y, Li J, Privratsky B, Wu E, Gao H, Huang C*, Wu M. Lyn   regulatesinflammatory responses in Klebsiella pneumoniae infection via the p38/NF-κBpathway. Eur J Immunol. 2014;44(3):763-73.

64: Xie N, Chen X, Zhang T, Liu B*, Huang C*. Using proteomics to identify the HBx interactome inhepatitis B virus: how can this inform the clinic? Expert Rev Proteomics. 2014;11(1):59-74.

63: Liu R, Li J, Xie K, Zhang T, Lei Y, Chen Y, Zhang L, Huang K, Wang K, Wu H, Wu M, Nice EC, Huang C*, Wei Y. FGFR4 promotes stroma-induced   epithelial-to-mesenchymaltransition in colorectal cancer. Cancer Res. 2013 ;73(19):5926-35.

62: Wen X, Wu J,Wang F, Liu B*, Huang C*, Wei Y. Deconvoluting the role of reactive oxygen speciesand autophagy in human diseases. Free Radic Biol Med. 2013 ; 65:402-10.

61: Liu R, Huang L, Li J, Zhou X, Zhang H, Zhang T, Lei Y, Wang K, Xie N, Zheng Y, Wang F, Nice EC,Rong L, Huang C*, Wei Y. HIV Infection in gastric epithelial cells. J Infect Dis. 2013 ;208(8):1221-30.

60: Liu B, Wen X, Huang C*, Wei Y. Unraveling the complexity of hepatitis B virus: from molecular understanding to therapeutic strategy in 50 years. Int J Biochem Cell Biol. 2013 Sep;45(9):1987-96.

59: Wu J, Xie N, Xie K, Zeng J, Cheng L, Lei Y, Liu Y, Song L, Dong D, Chen Y, Zeng R, Nice EC, Huang C*, Wei Y. GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer. Carcinogenesis. 2013 ;34(12):2861-9.

58: Yuan K, Xie K, Fox J, Zeng H, Gao H, Huang C*, Wu M*. Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice. Gastroenterology. 2013 Oct;145(4):853-64.e9.

57: Deng L, Lei Y, Liu R, Li J, Yuan K, Li Y, Chen Y, Liu Y, Lu Y, Edwards CK 3rd, Huang C*, Wei Y. Pyrvinium targets autophagy addiction to promote cancer cell death. Cell Death Dis. 2013 May 2;4:e614.

56: Zhang T, Xie N, He W, Liu R, Lei Y, Chen Y, Tang H, Liu B*, Huang C, Wei Y. An integrated proteomics and bioinformatics analyses of hepatitis B virus X interacting proteins and identification of a novel interactor apoA-I. J Proteomics. 2013 Jun 12;84:92-105.

55: Wang K, Zhang T, Dong Q, Nice EC, Huang C*, Wei Y. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis. 2013 Mar 14;4:e537.

54: Zeng J, Yang X, Cheng L, Liu R, Lei Y, Dong D, Li F, Lau QC, Deng L, Nice EC, Xie K*, Huang C. Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection. J Transl Med. 2013 Jan 7;11:6.

53: Zhou S, Liu R, Yuan K, Yi T, Zhao X*, Huang C*, Wei Y. Proteomics analysis of tumor microenvironment: Implications of metabolic and oxidative stresses in tumorigenesis. Mass Spectrom Rev. 2013 Jul-Aug;32(4):267-311.

52: Klionsky DJ, Abdalla FC...Canhua H, et al., Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-44.

51: Wang K, Yang T, Wu Q, Zhao X, Nice EC, Huang C*. Chemistry-based functional proteomics for drug target deconvolution. Expert Rev Proteomics. 2012 Jun;9(3):293-310.

50: Zhou S, Yi T, Liu R, Bian C, Qi X, He X, Wang K, Li J, Zhao X*, Huang C*, Wei Y. Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis. Mol Cell Proteomics. 2012 Jul;11(7):M112.017988. doi: 10.1074/mcp.M112.017988. Epub 2012 Apr 9.

49: Yuan K, Huang C*, Fox J, Laturnus D, Carlson E, Zhang B, Yin Q, Gao H, Wu M*. Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages. J Cell Sci. 2012 Jan 15;125(Pt 2):507-15.

48: Zhou S, Li Y, Huang F, Zhang B, Yi T, Li Z, Luo H, He X, Zhong Q, Bian C, Lin X, Qi X, Liu P, Huang C, Zhao X*, Wei Y. Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation. Cancer Lett. 2012 May 1;318(1):14-25.

47: Lei Y, Xie K, Huang K, Wu H, Huang C*. Chemistry-based functional proteomics to identify novel deubiquitylating enzymes involved in viral infection. Comb Chem High Throughput Screen. 2012 May 1;15(4):316-27.

46: Zhou M, Luo H, Li Z, Wu F, Huang C, Ding Z, Li R*. Recent advances in screening of natural products for antimicrobial agents. Comb Chem High Throughput Screen. 2012 May 1;15(4):306-15.

45: Ou L, Duan D, Wu J, Nice E, Huang C*. The application of high throughput siRNA screening technology to study host-pathogen interactions. Comb Chem High Throughput Screen. 2012 May 1;15(4):299-305.

44: Zeng J, Xie K, Wu H, Zhang B, Huang C*. Identification and functional study of cytokines and chemokines involved in tumorigenesis. Comb Chem High Throughput Screen. 2012 Mar;15(3):276-85.

43: Xie N, Huang K, Lei Y, Ran Y, Huang C*. Proteomics annotation of lipid rafts modified by virus infection. Comb Chem High Throughput Screen. 2012 Mar;15(3):253-65.

42: Liang S*, Xu Z, Xu X, Zhao X, Huang C, Wei Y. Quantitative proteomics for cancer biomarker discovery. Comb Chem High Throughput Screen. 2012 Mar;15(3):221-31.

41: Huang C. Modern omics-based platform for high throughput screening for novel drug targets. Comb Chem High Throughput Screen. 2012 Mar;15(3):201.

40: Wu J, Xie N, Zhao X, Nice EC, Huang C*. Dissection of aberrant GPCR signaling in tumorigenesis--a systems biology approach. Cancer Genomics Proteomics. 2012 Jan;9(1):37-50.

39: Xie N, Huang K, Zhang T, Lei Y, Liu R, Wang K, Zhou S, Li J, Wu J, Wu H, Deng C, Zhao X, Nice EC, Huang C*. Comprehensive proteomic analysis of host cell lipid rafts modified by HBV infection. J Proteomics. 2012 Jan 4;75(3):725-39.

38: Hu H, Deng C, Yang T, Dong Q, Chen Y, Nice EC, Huang C*, Wei Y. Proteomics revisits the cancer metabolome. Expert Rev Proteomics. 2011 Aug;8(4):505-33.

37: Zhou S, Liu R, Zhao X*, Huang C*, Wei Y. Viral proteomics: the emerging cutting-edge of virus research. Sci China Life Sci. 2011 Jun;54(6):502-12.

36: Lei Y, Huang K, Gao C, Lau QC, Pan H, Xie K, Li J, Liu R, Zhang T, Xie N, Nai HS, Wu H, Dong Q, Zhao X, Nice EC, Huang C*, Wei Y. Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells. Mol Cell Proteomics. 2011 Oct;10(10):M110.005397.

35: Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, Zeng J, Zhang T, Wu H, Chen L, Huang C*, Wei Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy. 2011 Sep;7(9):966-78.

34: Zeng D, Zhang T, Zhou S, Hu H, Li J, Huang K, Lei Y, Wang K, Zhao Y, Liu R, Li Q, Wen Y, Huang C. Proteomic analyses of gastric cancer cells treated with vesicular stomatitis virus matrix protein. Protein J. 2011 Jun;30(5):308-17.

33: Yuan K, Huang C*, Fox J, Gaid M, Weaver A, Li G, Singh BB, Gao H, Wu M. Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor kappaB (NF-kappaB). J Biol Chem. 2011 Jun 17;286(24):21814-25.

32: Zhou S, Huang C*, Wei Y. The metabolic switch and its regulation in cancer cells. Sci China Life Sci. 2010 Aug;53(8):942-58.

31: Li J, Liu R, Lei Y, Wang K, Lau QC, Xie N, Zhou S, Nie C, Chen L, Wei Y, Huang C*. Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy. 2010 Aug;6(6):711-24.

30: Liu R, Wang K, Yuan K, Wei Y, Huang C. Integrative oncoproteomics strategies for anticancer drug discovery. Expert Rev Proteomics. 2010 Jun;7(3):411-29.

29: Ren F, Wu H, Lei Y, Zhang H, Liu R, Zhao Y, Chen X, Zeng D, Tong A, Chen L, Wei Y, Huang C. Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. Mol Cancer. 2010 Apr 19;9:81.

28: Yuan K, Lei Y, Huang C. Application of chemistry-based functional proteomics to screening for novel drug targets. Comb Chem High Throughput Screen. 2010 Jun;13(5):414-21.

27: Li Z, Min W, Huang C, Bai S, Tang M, Zhao X. Proteomics-based approach identified differentially expressed proteins with potential roles in endometrial carcinoma. Int J Gynecol Cancer. 2010 Jan;20(1):9-15.

26: Kannan S, Huang H, Seeger D, Audet A, Chen Y, Huang C, Gao H, Li S, Wu M. Alveolar epithelial type II cells activate alveolar macrophages and mitigate P. Aeruginosa infection. PLoS One. 2009;4(3):e4891.

25: He J, Huang C, Tong A, Chen B, Zeng Z, Zhang P, Wang C, Wei Y. Proteomic analysis of cervical cancer cells treated with suberonylanilide hydroxamic acid. J Biosci. 2008 Dec;33(5):715-21.

24: Gou LT, Tong AP, Chen LJ, Tang MH, Chen B, Liang SF, Huang C, Wei YQ. Comparative plasma membrane-associated proteomics of immortalized human hepatocytes.   Biochemistry (Mosc). 2008 Nov;73(11):1200-6.

23: Tong A, Gou L, Lau QC, Chen B, Zhao X, Li J, Tang H, Chen L, Tang M, Huang C, Wei YQ. Proteomic profiling identifies aberrant epigenetic modifications induced by hepatitis B virus X protein. J Proteome Res. 2009 Feb;8(2):1037-46.

22: Gao F, Huang C, Lin M, Wang Z, Shen J, Zhang H, Jiang L, Chen Q. Frequent   inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas. J Cancer Res Clin Oncol. 2009 May;135(5):739-47.

21: Li Z, Huang C, Bai S, Pan X, Zhou R, Wei Y, Zhao X. Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach. Int J Cancer. 2008 Nov 15;123(10):2377-83.

20: Liu R, Li Z, Bai S, Zhang H, Tang M, Lei Y, Chen L, Liang S, Zhao YL, Wei Y, Huang C. Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway. Mol Cell Proteomics. 2009 Jan;8(1):70-85.

19: Liang S, Xu Y, Shen G, Zhao X, Zhou J, Li X, Gong F, Ling B, Fang L, Huang C, Wei Y. Gene expression and methylation status of 14-3-3sigma in human renal carcinoma tissues. IUBMB Life. 2008 Aug;60(8):534-40.

18: Tong A, Wu L, Lin Q, Lau QC, Zhao X, Li J, Chen P, Chen L, Tang H, Huang C, Wei YQ. Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model. Proteomics. 2008 May;8(10):2012-23.

17: Wang Z, Jiang L, Huang C, Li Z, Chen L, Gou L, Chen P, Tong A, Tang M, Gao F, Shen J, Zhang Y, Bai J, Zhou M, Miao D, Chen Q. Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma. Mol Cell Proteomics. 2008 Sep;7(9):1639-50.

16: Li Z, Liu Y, Zhao X, Pan X, Yin R, Huang C, Chen L, Wei Y. Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells. Eur J Obstet Gynecol Reprod Biol. 2008 Sep;140(1):95-102.

15: Li Z, Zhao X, Bai S, Wang Z, Chen L, Wei Y, Huang C. Proteomics identification of cyclophilin a as a potential prognostic factor and therapeutic target in endometrial carcinoma. Mol Cell Proteomics. 2008 Oct;7(10):1810-23.

14: Wang YS, Wang GQ, Wen YJ, Wang L, Chen XC, Chen P, Kan B, Li J, Huang C, Lu Y, Zhou Q, Xu N, Li D, Fan LY, Yi T, Wu HB, Wei YQ. Immunity against tumor angiogenesis induced by a fusion vaccine with murine beta-defensin 2 and mFlk-1.   Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6779-87.

13: Tong A, Zhang H, Li Z, Gou L, Wang Z, Wei H, Tang M, Liang S, Chen L, Huang C, Wei Y. Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. Cancer Chemother Pharmacol. 2008 Apr;61(5):791-802.

12: Shen J, Huang C, Jiang L, Gao F, Wang Z, Zhang Y, Bai J, Zhou H, Chen Q. Enhancement of cisplatin induced apoptosis by suberoylanilide hydroxamic acid in human oral squamous cell carcinoma cell lines. Biochem Pharmacol. 2007 Jun15;73(12):1901-9.

11: Chao G, Fan L, Jia W, Qian Z, Gu Y, Liu C, Ni X, Li J, Deng H, Gong C, Gou M, Lei K, Huang A, Huang C, Yang J, Kan B, Tu M. Synthesis, characterization and hydrolytic degradation of degradable poly(butylene terephthalate)/poly(ethyleneglycol) (PBT/PEG) copolymers. J Mater Sci Mater Med. 2007 Mar;18(3):449-55.

10: Huang C, Ida H, Ito K, Zhang H, Ito Y. Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatment. Biochem Pharmacol. 2007 Apr 1;73(7):990-1000.

9: Lau QC, Raja E, Salto-Tellez M, Liu Q, Ito K, Inoue M, Putti TC, Loh M, Ko TK, Huang C, Bhalla KN, Zhu T, Ito Y, Sukumar S. RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res. 2006 Jul 1;66(13):6512-20.

8: Ito K, Liu Q, Salto-Tellez M, Yano T, Tada K, Ida H, Huang C, Shah N, Inoue M, Rajnakova A, Hiong KC, Peh BK, Han HC, Ito T, Teh M, Yeoh KG, Ito Y. RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res. 2005 Sep 1;65(17):7743-50. Erratum in: Cancer Res. 2006 Mar 15;66(6):3345.

7: Zhang X, Huang C, Tang X, Zhuang Y, Hew CL. Identification of structural proteins from shrimp white spot syndrome virus (WSSV) by 2DE-MS. Proteins. 2004 May 1;55(2):229-35.

6: Huang C, Zhang X, Gin KY, Qin QW. In situ hybridization of a marine fish virus, Singapore grouper iridovirus with a nucleic acid probe of major capsid protein. J Virol Methods. 2004 May;117(2):123-8.

5: Zhang X, Huang C, Qin Q. Antiviral properties of hemocyanin isolated from shrimp Penaeus monodon. Antiviral Res. 2004 Feb;61(2):93-9.

4: Huang C, Zhang X, Lin Q, Xu X, Hew CL. Characterization of a novel envelope protein (VP281) of shrimp white spot syndrome virus by mass spectrometry. J Gen Virol. 2002 Oct;83(Pt 10):2385-92.

3: Huang C, Zhang X, Lin Q, Xu X, Hu Z, Hew CL. Proteomic analysis of shrimp white spot syndrome viral proteins and characterization of a novel envelope protein VP466. Mol Cell Proteomics. 2002 Mar;1(3):223-31.

2: Zhang X, Huang C, Xu X, Hew CL. Identification and localization of a prawn white spot syndrome virus gene that encodes an envelope protein. J Gen Virol. 2002 May;83(Pt 5):1069-74.

1: Zhang X, Huang C, Xu X, Hew CL. Transcription and identification of an envelope protein gene (p22) from shrimp white spot syndrome virus. J Gen Virol. 2002 Feb;83(Pt 2):471-7.